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RELEASE CLAIMS AND SUPPORTIVE SCIENCE

Click on one of the links below to view research and support for that topic.

Stress
Energy
Weight Management
Mental Cognition
Glucose Release
Immune Support
Adaptogen
Anti-Aging

STRESS

Helps increase resistance to fatigue, stress, tension
Helps the body cope with stress.
Anti-stress formula promotes emotional well-being.
Helps the body cope with stress .

Supported by:

Abreu R. Stress, millennium plague. India Today. 1999 Sep;65.

Archana R, Namasivayam A. Antistressor effect of Withania somnifera. Journal of Ethnopharmacology. 1999;64:91-93.

Bhattacharya SK, Goel RK, Kaur R, Ghosal S. Anti-stress activity of Sitoindosides VII and VIII, new Acylsterylglucosides from Withania Somnifera. Phytotherapy Research. 1987;1(1):32-7.

Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera.. Indian Journal of Experimental Biology. 1997;35:236-239.

Dhuley JN. Effect of Ashwagandha on lipid peroxidation in stress-induced animals. Journal of Ethnopharmacology. 1998;60:173-8.

Ghosal S, Lal J, Srivastava R et al. Immunomodulatory and CNS effects of Sitoindosides IX and X, two new glycowithanolides from Withania somnifera. Phytotherapy Research. 1989;3(5):201-6.

Ghosal S. Natural products with immunological effects. Indian J Indg Med. 1991;12:1-7.

Grandhi A, Mujumdar AM, Patwardhan B. A comparative pharmacological investigation of Ashwagandha and Ginseng. Journal of Ethnopharmacology. 1994;44:131-5.

Ramarao P, Rao KT, Srivastava RS, Ghosal S. Effects of glycowithanolides from Withania somnifera on morphine-induced inhibition of intestinal motility and tolerance to analgesia in mice. Phytotheapy Research. 1995;9:66-68.

Selye H. The evolution of stress concept. Am Scientist. 1973;61:692-698.

Shah LP, Patil SP, Patil J. Observations on clinical evaluation of indigenous herbal drugs in the treatment of mental illnesses. Indian Journal of Pharmacology. 1997;29:S347-S349.

Singh A, Saxena E, Bhutani KK. Adrenocorticosterone alterations in male, albino mice treated with Trichopus zeylanicus, Withania somnifera and Panax ginseng preparations. Phytotherapy Research. 2000;14:122-125.

Tongia SK, Bose S, Jain HL. Cytoprotective and efficiency optimizing effect of Eumil against routine mental & physical stress in bank clerks and gymnast-body builders. Indian J Indg Med. 1995-96;17(2):13-24.

Vaidya ADB. The status and scope of Indian medicinal plants acting on central nervous system. Indian Journal of Pharmacology. 1997;29:S340-S343.

ENERGY

Enhances energy levels while helping to alleviate general fatigue.
Boosts energy and reduces fatigue
Helps restore and sustain energy levels
Energy Builder
Boosts Energy Levels
Builds stamina

Supported by:

Agarwal R, Diwanay S, Patki P, Patwardhan B. Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. Journal of Ethnopharmacology. 1999;67:27-35.

Bhattacharya SK, Satyan KS, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera.. Indian Journal of Experimental Biology. 1997;35:236-239.

Davis L, Kuttan G. Immunomodulatory activity of Withania somnifera. Journal of Ethnopharmacology. 2000;71:193-200.

Dhuley JN. Effect of Ashwagandha on lipid peroxidation in stress-induced animals. Journal of Ethnopharmacology. 1998;60:173-8.

Ghosal S, Lal J, Srivastava R et al. Immunomodulatory and CNS effects of Sitoindosides IX and X, two new glycowithanolides from Withania somnifera. Phytotherapy Research. 1989;3(5):201-6.

Ghosal S. Natural products with immunological effects. Indian J Indg Med. 1991;12:1-7.

Grandhi A, Mujumdar AM, Patwardhan B. A comparative pharmacological investigation of Ashwagandha and Ginseng. Journal of Ethnopharmacology. 1994;44:131-5.

Mukhopadhaya B, Chokrabarti A, Ghosal S, Bhattacharya SK. Immunomodulatory properties of some Indian medicinal plants. In Emerging Drugs Volume 1, Molecular Aspects of Asian Medicines, Eds. Akitane Mori, M.D., Ph.D., Tetsuo Satoh, Ph.D., PJD Publications Ltd. (Westbury, NY) 2001.

Pallabi DE, Dasgupta SC, Gomes A. Immunopotentiating and immunoprophylactic activities of Immue 21, a polyherbal product. Indian Journal of Pharmacology. 1998;30:163-8.

Shah LP, Patil SP, Patil J. Observations on clinical evaluation of indigenous herbal drugs in the treatment of mental illnesses. Indian Journal of Pharmacology. 1997;29:S347-S349.

Vaidya ADB. The status and scope of Indian medicinal plants acting on central nervous system. Indian Journal of Pharmacology. 1997;29:S340-S343.

Ziauddin M, Phansalkar N, et al. Studies on the immunomodulatory effects of Ashwagandha. Journal of Ethnopharmacology. 1996;50:69-76.

WEIGHT MANAGEMENT

Helps manage weight by controlling stress-related eating
Supports healthy weight management by inhibiting stress related overeating.
Helps manage stress-induced appetite.
Helps control stress-related overeating.

Supported by:

Grandhi A, Mujumdar AM, Patwardhan B. A comparative pharmacological investigation of Ashwagandha and Ginseng. Journal of Ethnopharmacology. 1994;44:131-135.

Dallman M, la Fleur S, Pecoraro N, Gomex F, Houshyar H, Akana S. Minireview: Glucocorticoids-Food Intake, Abdominal Obesity, and Wealthy Nations in 2004. Endocrinology Vol. 145, No.6 2633-2638.

Hjemdahl P. Editorial: Stress and the Metabolic Syndrome An Interesting but Enigmatic Association Circulation 2002;106:2634

Rosmond R, Dallman M, Bjorntorp P. Stress-Related Cortisol Secretion in Men:Relationship with Abdominal Obesity and Endocrine, Metabolic and Hemodynamic Abnormalities The Journal of Clinical Endocrinology & Metabolism Vol. 83, No.6 1853-1859

Fruehwald-Schultes B, Kern W, Bong W, Wellhoener P, Kerner W, Born J, Fehm H, Peters A. Supraphysiological Hyperinsulinemia Acutely Increases Hypothalamic-Pituitary-Adrenal Secretory Activity in Humans. The Journal of Clinical Endocrinology & Metabolism Vol. 84, No. 9 3041-3046.

Vicennati V, Pasquali R Abnormalities of the Hypothalamic-Pituitary-Adrenal Axis in Nondepressed Women with Abdominal Obesity and Relations with Insulin Resistance: Evidence for a Central and a Peripheral Alteration. The Journal of Clinical Endocrinology & Metabolism Vol. 85, No. 11 4093-4098.

Rosmond R. Stress induced disturbances of the HPA axis: a pathway to Type 2 diabetes? Med Sci Monit, 2003;9(2):RA35-39

LaValle J. Stress: The Hidden Factor for Weight Gain Nutrition Science News April 2001.

MENTAL COGNITION

Helps alleviate mental fatigue.
Helps sharpen focus and mental stamina.
Boosts mental clarity and concentration.

Supported by:

Bhattacharya S, Kumar A. Effects of glycowithanolides from Withania somnifera on an animal model of Alzheimer’s disease and perturbed central cholinergic markers of cognition in rats. Phytotherapy Research. 1995;9:110-113.

Ghosal S, Lal J, Srivastava R, et al. Immunomodulatory and CNS effects of sitoindosides IX and X, two new glycowithanolides from Withania somnifera. Phytotherapy Research. 1989;3(5):201-206.

Naidu P, Singh A, Kulkarni S. Effect of Withania somnifera root extract on haloperidol-induced orofacial dyskinesia: possible mechanisms of action. Journal of Medicinal Food. 2003;6(2):107-114.

Kulkarni SK, Sharma A, Verma A, Ticku MK. Gaba receptor mediated anticonvulsant action of Withania somnifera Root extract. Indian Drugs. 1993;7(30):305-312.

Shukla SD, Jain S, Sharma K, Bhatnagar M. Stress induced neruon degneration and protective effects of Semecarpus anacardium Linn. and Withania somnifera Dunn. in hippocampus of albino rats: an ultrastructural study. Indian Journal of Experimental Biology. 2000;38:1007-1013.

Bhattacharya S, Satyan K, Ghosal S. Antioxidant activity of glycowithanolides from Withania somnifera. Indian Journal of Experimental Biology Vol. 35, March 1997, pp. 236-239.

Prabhu M., Rao A., Karanth K.S. Neuropharmacological Activity of Withania somnifera Fitoterapia Volume LXL, No. 3, 1990

Karnick C.R., A double-blind, placebo-controlled clinical studies on the effects of Withania somnifera and Panax Ginseng Extracts on psychomotor performance in healthy Indian volunteers. Indian Medicine Vol. 3 No. 2,3, April-July 1991.

GLUCOSE RELEASE

Helps balance blood sugar levels

Mishra LC, Singh B, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review. Alternative Medicine Review. 2000;5(4):334-346.

IMMUNE SUPPORT

Helps support healthy immune function.
Helps support cellular defenses.
Helps support the body’s immune defense.
Helps enhance the body’s own macrophage production.

Supported by:

Bhargava HN. Opioid peptides, receptors and immune functions. Drugs Abuse Res. (monograph), USA. 1990;86:220-3.

Chauhan RS. Effect of immuplus on humoral and cell mediated immunity in dogs. J. Immunol. Immunopathol. 1999;1:54-57.

Chattopadhyay S, Chaudhury S, Ghosal S. Activation of peritoneal macrophages by sitoindosides. Planta Med. 1987;54:16-9.

Davis L, Kuttan G. Immunomodulatory activity of Withania somnifera. Journal of Ethnopharmacology. 2000;71:193-200.

Ehrke N, Mihich E. Effects of anticancer agents on immune responses. TIPS. 1985:412-417.

Ghosal S, Lal J, Srivastava R et al. Immunomodulatory and CNS effects of Sitoindosides IX and X, two new glycowithanolides from Withania somnifera. Phytotherapy Research. 1989;3(5):201-6.

Ghosal S. Natural Products with Immunological Effects. Indian J Indg Med. 1991;12:1-7.

Jankovic BD. Neural tissue hypersensitivity in psychiatric disorders with immunological features. J Immunol. 1985;135:853S-857S.

Pallabi DE, Dasgupta SC, Gomes A. Immunopotentiating and immunoprophylactic activities of Immue 21, a polyherbal product. Indian Journal of Pharmacology. 1998;30:163-8.

Ziauddin M, Phansalkar N, et al. Studies on the immunomodulatory effects of Ashwagandha. Journal of Ethnopharmacology. 1996;50:69-76.

ADAPTOGEN

Helps to regulate and balance healthy metabolic function.
Adaptogen enhances energy levels while helping to alleviate fatigue.